This semi-synthetic flavone is the most potent vascular growth inhibitor in several in vitro models and in vivo shows hydroxy radical scavenging properties as well that inhibit the transformation of pre cancerous cells into cancerous cells. The active moiety has a better toxicological profile than an already approved human drug and is thus a perfect candidate for prostate adenocarcinoma prevention and adjunct therapy.
Although discussions are advanced with 2 partners, licensing opportunities and R&D collaborations are welcome.
We found a new indication for this chemical, that is already approved as a drug in many countries at higher dose regimen, as an antibiotic enhancer as it is capable of rendering multiresistant Streptococcus pneumoniae sensitive to penicillin + AI 1005 in mice pneumonia lethal models.
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